PRRSV pathology in the lungs

Lungs of a piglet exterminated 14 days PI, inoculated with higly pathogenic Type I subtype 3 strain Lena

The tissue damage is the consequence of direct apoptosis (and necrosis) of alveolar macrophage and their neighboring cells due to the release of apoptotigenic cytokines, reactive oxygen species, and nitric oxide.

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