Manuel Toledo Castillo

Agropecuaria Casas Nuevas - Spain Author

Manuel Toledo Castillo, doctor of veterinary medicine from the University of Murcia, graduated with a degree in veterinary medicine from the University of Cordoba in 1987, Master in management and direction of agricultural cooperatives in 1990 Master in pig farming from the University of Murcia.

Joaquín Mompié Monte-Agudo Award, to the professional career awarded by the Veterinary College of Murcia in 2011.

National Research Award Grupo Fuertes 2017

XXIII Francisco Fernández López National Research Award (awarded by the College of Veterinarians of Almería).

From 1990 to 1992 he worked as Technical Director of the UGA cooperative in the mountains of Cuenca.

From 1992 to 1994 he worked as a local health worker for the Junta de Comunidades de Castilla la Mancha.

From 1994 to 1995 worked as technical director of the pig ADS Baja Serranía de Cuenca

From 1995 to the end of 2017 he worked as a production veterinarian at Juan Jimenez Garcia, in Lorca (Murcia).

Since 2018 he has worked as a production veterinarian at Agropecuaria Casas Nuevas, Grupo Francés.

In 2024, the Royal Academy of Veterinary Sciences of Spain awarded him the I Laboratorios MEVET "Carlos Buxadé Carbó" Award for his research: "Management guide for sows and piglets to optimize welfare and sustainability. New experiences."

Updated CV 26-Jan-2024

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28-Apr-2026Rocío García EspejoVerotoxin, or Shiga toxin 2e (Stx2e), is an endotoxin whose functional mechanism in the body differs from the exotoxin responsible for enteropathogenic E. coli. Stx2e is a toxin that induces symptoms of edema disease in the host. A study titled Effect of zinc supplementation on Shiga toxin 2e-producing Escherichia coli in vitro found that Stx2e production by STEC was significantly lower in media containing supplemental zinc.

On the other hand, when certain classes of antimicrobials (such as ampicillin) are used to treat edema disease, the produced Stx2e accumulates within the cell body and can be released upon the destruction of the bacterial cell, leading to an exacerbated worsening of clinical symptoms. Therefore, to avoid the massive release of Stx2e, it is crucial to understand the antibacterial mechanism of action employed. Furthermore, it has also been proven that α-hemolysin (another virulence factor) produced by this type of bacteria is also significantly lower in the presence of zinc.

In conclusion, this study demonstrates that zinc inhibits the production of Stx2e and hemolysin by preventing the synthesis of these proteins within the bacterial cytoplasm.
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12-Mar-2021Joe Crenshaw JoeGood job by the authors describing these multiple issues related to disease and weaning stress and the longer term impact on performance. Getting the pigs started on feed is a critical component of longer term performance and health.
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23-May-2018manuel toledo castillothe endocrine and metabolic changes that occur at the end of pregnancy, by increasing feed intake, increases the risk of edema
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