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Bacillus licheniformis and Sodium Butyrate in weanling pigs against Salmonella

Bacillus licheniformis and Sodium Butyrate may reduce the colonization of Salmonella in piglets.

Thursday 2 October 2014 (4 years 3 months 20 days ago)

The objective of the study was to evaluate the efficacy of Bacillus licheniformis or Sodium Butyrate in weanling pigs orally challenged with Salmonella Typhimurium. Seventy-two piglets (28 d old, 8.21 ± 0.79 kg) were divided into 24 pens allocated to 3 experimental diets: (1) CTR, base diet without additives; (2) BL, base diet supplemented with 1 kg/t of 109 CFU/kg of feed of Bacillus licheniformis; and (3) BUT, base diet supplemented with 3kg/t of Sodium butyrate (containing 70% sodium butyrate protected with vegetable fat). The base diet was multicereal (corn, wheat, and barley) with selected protein sources (soybean meal 44, fishmeal, and bovine sweet whey), without antibiotics and met NRC 2012 requirements. Consumption and weight gain of the animals were monitored during the trial (16 d). After a week of adaptation, the animals were orally inoculated with Salmonella Typhimurium (1 × 108 CFU). Parameters evaluated after the oral challenge were fecal consistency, rectal temperature (24 and 72 h post-inoculation, PI) and fecal shedding of Salmonella (d 0, 1, and 7 PI). Moreover, on d 4 and 8 PI, 1 animal in each pen was euthanized to evaluate the serological inflammatory response (TNFα and Pig-Map), the microscopic ileal morphology, and the presence of Salmonella in the colon.

No significant differences between treatments were seen on performance, fecal consistency, rectal temperature or inflammatory markers (P > 0.05). However, a trend to reduction was observed in Salmonella prevalence in feces on d 7 PI (100, 75, and 75, P = 0.074) and significant reduction in colon on d 8 PI (88, 50, and 63, P = 0.043), for CTR, BL, and BUT, respectively. Besides, on d 4 PI crypt depth showed a tendency to increase with the 2 supplemented diets (203, 239, and 251 μm, SEM ± 15.9, P = 0.107), for CTR, BL, and BUT, respectively.

The results obtained demonstrate that the administration of Bacillus licheniformis (109 CFU/kg) or sodium butyrate (3kg/mT) could improve intestinal morphology and reduce the colonization and fecal shedding of Salmonella Typhimurium in piglets.

Barba-Vidal, E., Castillejos, L., Buttow Roll, V. F., Mallo, J. J. and Martín-Orúe, S. Evaluation of the efficacy of Bacillus licheniformis or sodium butyrate in front of a Salmonella Typhimurium oral challenge in piglets. J. Anim. Sci Vol. 92, E-Suppl. 2 Page 240, abstract 0482.

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