Foot-and-mouth disease

Foot-and-mouth disease is one of the most important vesicular diseases.

Description

There are four swine vesicular diseases that are not clinically differentiated: foot and mouth disease, vesicular disease, vesicular exanthema, and vesicular stomatitis.

Foot and mouth disease (FMD) is considered to be the most contagious livestock disease and the most significant restriction factor regarding international trade of animals and animal products. Essentially, all cloven-hoofed species are susceptible.

Foot-and-mouth disease belongs to the Picornaviridae virus family of which there are more than 60 strains classified into seven serotypes.

All ages

  • High fever.
  • Lameness.
  • Loss of appetite
  • Depression.
  • In nursing piglets sudden death is common due to heart failure.
  • Vesicles up to 30 mm in diameter on the coronary bands, mouth, soft tissues of the legs and around the hoof. These vesicles can also be present on lactating sows’ teats.
  • Salivation and chewing movements.
  • During the first 24 hours, many of the vesicles burst, leaving erosive lesions.
  • If pigs are not slaughtered, some can completely lose their hoofs, and sows can abort due to the fever.
  • There can be an increase in nursing pig mortality, which is usually the first sign. 

Serological and PCR tests are needed. Foot-and-mouth disease does not differentiate clinically from the rest of the vesicular diseases. Laboratory samples must include blood, vesicular tissue and fluid, when possible. 
 

More info on lab diagnostics

There is no treatment. There are some effective vaccines for specific serotypes. 

FAQs

  • Asia 1
  • South Africa Type 1 (SAT 3)
  • South Africa Type 1 (SAT 2)
  • South Africa Type 1 (TSS 1)
  • C
  • A
  • O

It should be noted that there is no cross-protection between serotypes.

Foot and mouth disease affects all cloven-hoofed animals, both domestic and wild, and thus affects different species of bovines, ovines, goats, and suids. This large group includes pigs and wild boars, cattle, sheep and mouflons, goats, gazelles, antelopes, buffalo, and bison. Camelids (camels, dromedaries, llamas, and vicunas) are less susceptible to contracting the disease.

The incubation period for foot and mouth disease is 2 to 14 days, the most common being 2 to 5 days. In small ruminants (sheep and goats), the maximum period may be 21 days.

The main symptoms are: Fever, loss of appetite, prostration, lameness, ptyalism and sialorrhea (excessive salivation and difficulty keeping saliva in the mouth) agalactia, abortions; more evident in pigs and cattle and less evident in small ruminants.

The most characteristic lesions are vesicles on the tongue, gums, buccal mucosa, hard and soft palate, lips, nostrils, snout, coronary ridge, teats, udders, and interdigital space.

For more information: https://www.pig333.com/pig-diseases/foot-and-mouth-disease_43

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Affectation map

World Organisation for Animal Health (WOAH) (2025) – WAHIS periodical extraction of early warning outbreak data. Retrieved on 12/2/2025. Data extracted by 333 Corporate 1998, SL. WOAH bears no responsibility for the integrity or accuracy of the data contained herein, not limited to: any deletion, manipulation, or reformatting of data that may have occurred beyond its control.

Atlas of pathology

Resources

OTHER SOURCES

 video-icon.pngWhat you need to know about Foot and Mouth Disease. FAO
Video explaining the main transmission routes and clinical signs of the disease.

 pdf-icon.pngFoot and Mouth Disease Pocket Guide. USDA-APHIS
More than 60 pictures with lesions caused by foot and mouth disease virus after an experimental infection, both in domestic and wild pigs.

pdf-icon.png Foot and Mouth Disease Technical Disease Card. World Organisation for Animal Health (WOAH)
Updated information from WOAH about the disease.

Abstracts

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