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To better assess the risk posed by the A(H1N1) 2009 in the actual situation of swine farms, we sought to analyze whether a previous infection with a circulating European avian-like swine A/Swine/Spain/53207/2004 (H1N1) influenza virus (hereafter referred to as SwH1N1) generated or not cross-protective immunity against a subsequent infection with the new human pandemic A/Catalonia/63/2009 (H1N1) influenza virus (hereafter referred to as pH1N1) 21 days apart. Pigs infected only with pH1N1 had mild to moderate pathological symptoms, consisting on broncho-interstitial pneumonia. However, pigs inoculated with SwH1N1 virus and subsequently infected with pH1N1 had very mild lung lesions, apparently attributed to the remaining lesions caused by SwH1N1 infection. These later pigs also exhibited boosted levels of specific antibodies. Finally, animals firstly infected with SwH1N1 virus and latter infected with pH1N1 exhibited undetectable viral RNA load in nasal swabs and lungs after challenge with pH1N1, indicating a cross-protective effect between both strains.
Nuria B, Joaquim S, Lorena C, Tufaria M, Elisa C, Gerard E MV, Meritxell SG, Marta PS, Monica PM, Jose I N, Francesc X A, Lorenzo F, Sonia P, Natalia M, Albert B, Mariano D, Maria M, Experimental infection with H1N1 european swine influenza virus protects pigs from an infection with the 2009 pandemic H1N1 human influenza virus, Vet Res. 2010 Jul 29;41(5):74. [Epub ahead of print]
