Pigs used as a model for studying human tuberculosis, for the first time

The Unitat de Tuberculosi Experimental (UTE), Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP) has developed a new experimental model in minipigs for Mycobacterium tuberculosis, in collaboration with the CReSA. The mini-pig model highlights new aspects that could be a key to a better understanding tuberculosis infection control in humans.
Wednesday 12 May 2010 (8 years 1 months 10 days ago)
The Unitat de Tuberculosi Experimental (UTE), Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP) has developed a new experimental model in minipigs for Mycobacterium tuberculosis, in collaboration with the CReSA. The mini-pig model highlights new aspects that could be a key to a better understanding tuberculosis infection control in humans.

Investigators of the CReSA developed and exhaustive study of the physiopathology of the disease and evaluated the cell-mediated and humoral immunological responses in: 1) infected animals, 2) infected animals and treated with Isoniazide and 3) infected animals and treated with Isoniazide and inoculated with 2 doses of a vaccine based in M. tuberculosis fragments. Immunological analysis were carried out by means of ELISPOT for IFN-γ and ELISA for detection of IFN-γ, TNF-α, IL-4, IL-10 and IL-12, against 4 antigens (PPD, ESAT-6, 85B and 16KDa) of the pathogen and against an attenuated strain (BCG). For the study of the humoral response a ELISA homemade was developed for detecting the antibodies created against the PPD.

http://www.cresa.es/cresa3/default.asp?mod=strmenu01&anio=2010&sub=noticia154

Swine news

Article Comments

This area is not intended to be a place to consult authors about their articles, but rather a place for open discussion among pig333.com users.

Access restricted to 333 users. In order to post a comment you must be logged in.

Not a registered user of 333?sign upand access swine prices, the search engine, ...
It is fast and free
Are you registered in 333?LOGINIf you've forgotten your password we'll send it to you here

tags

Swine News

Swine industry news in your email

You are not subscribed to this list

22-Jun-201815-Jun-201808-Jun-201801-Jun-2018

Log in and sign up on the list

Not a registered user of 333?sign upand access swine prices, the search engine, ...
It is fast and free
Are you registered in 333?LOGINIf you've forgotten your password we'll send it to you here