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Pigs used as a model for studying human tuberculosis, for the first time

The Unitat de Tuberculosi Experimental (UTE), Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP) has developed a new experimental model in minipigs for Mycobacterium tuberculosis, in collaboration with the CReSA. The mini-pig model highlights new aspects that could be a key to a better understanding tuberculosis infection control in humans.
12 May 2010
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The Unitat de Tuberculosi Experimental (UTE), Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP) has developed a new experimental model in minipigs for Mycobacterium tuberculosis, in collaboration with the CReSA. The mini-pig model highlights new aspects that could be a key to a better understanding tuberculosis infection control in humans.

Investigators of the CReSA developed and exhaustive study of the physiopathology of the disease and evaluated the cell-mediated and humoral immunological responses in: 1) infected animals, 2) infected animals and treated with Isoniazide and 3) infected animals and treated with Isoniazide and inoculated with 2 doses of a vaccine based in M. tuberculosis fragments. Immunological analysis were carried out by means of ELISPOT for IFN-γ and ELISA for detection of IFN-γ, TNF-α, IL-4, IL-10 and IL-12, against 4 antigens (PPD, ESAT-6, 85B and 16KDa) of the pathogen and against an attenuated strain (BCG). For the study of the humoral response a ELISA homemade was developed for detecting the antibodies created against the PPD.

http://www.cresa.es/cresa3/default.asp?mod=strmenu01&anio=2010&sub=noticia154

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