Phytic acid supplementation did not affect (P > 0.05) villous height (VH) and VH to crypt depth (CD) ratio, but decreased (P < 0.05) CD in the jejunum. Phytase supplementation did not affect (P > 0.05) VH, CD and VH to CD ratio. Phytic acid supplementation reduced SGLT1 gene expression in duodenum, jejunum and ileum by 1.1, 5.4 and 2.4 folds, respectively. Phytase supplementation increased SGLT1 gene expression in jejunum by 2.6 folds, but reduced the expression of the same in the duodenum and ileum by 2.0 and 4.0 folds, respectively.
In conclusion, PA reduced the CD in the jejunum and the SGLT1 gene expression in the duodenum, jejunum and ileum, whereas phytase supplementation increased the expression of the SGLT1 in the jejunum. The reduced SGLT1 gene expression by PA implies that the latter reduces nutrient utilization in pigs partly through reduced expression of the SGLT1 that is involved in glucose and sodium absorption. The increased expression of the SGLT1 in jejunum by phytase supplementation implies that the latter alleviates the negative effects of PA partly through increased expression of the SGLT1.
TA Woyengo, JC Rodriguez-Lecompte, O Adeola, and CM Nyachoti, 2010. Journal of Animal Science, 88 (E-Suppl. 2):285.