In a PhD project at the National Food Institute, Technical University of Denmark, the latest technologies within whole genome sequencing were exploited to develop new methods to identify genes which are important for the survival of MRSA in pigs.
In her PhD project at the National Food Institute, PhD student Mette Theilgaard exploited the latest technologies within whole genome sequencing and studied the entire DNA of MRSA CC398.
These studies have resulted in new methods, high-throughput approaches, which can identify genes important for the survival of MRSA in pigs. High-throughput approaches can identify those genes in the total gene pool of the bacteria which are essential, or the presence of which is advantageous, for the bacteria under some given circumstances.
LA-MRSA ST398 is a new type and has turned out to be particularly successful in colonisation of pigs, from where it may transmit to humans. By studying which genes are essential for the bacteria in pigs it may be possible for researchers to identify the factors important for the bacterium to colonise on pigs. We still don’t know which specific genetic factors in this MRSA type facilitate the spread from animals to humans.
Tuesday 5 August, 2014/ DTU/ Denmark.