European Union: EFSA scientific opinion on safety and efficacy of methionine-zinc

The additive Met-Zinc is considered an efficacious source of zinc for all animal species/categories.

Tuesday 29 January 2013 (5 years 4 months 24 days ago)

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on safety and efficacy of methionine-zinc, technically pure (Met-Zinc) as compound of trace element for all species, and as amino acid for ruminants.

Based on published literature, the FEEDAP Panel concludes that additive Met-Zinc is safe for all animal species/categories considering that its use in feed is first limited by the regulatory maximum content of zinc. However, its contribution to dietary methionine needs consideration when formulating diets.

Methionine from Met-Zinc would be incorporated into animal tissues and products, showing a constant amino acid pattern. Zinc from this feed additive would not lead to higher zinc deposition in tissues/products, and hence consumer exposure, than zinc from other authorised zinc sources. The FEEDAP Panel concludes that the use of Met-Zinc in animal nutrition is safe for consumers when used up to the maximum authorised level of zinc.
In the absence of data, the compound should be considered as a potential irritant to skin and eye and a skin sensitiser. Zinc compounds are hazardous by inhalation; Met-Zinc shows a high dusting potential, thus exposure by inhalation represents a hazard to persons handling the additive.

In studies comparing bioavailability of zinc from Met-Zinc and from zinc oxide, a higher digestibility and body retention of zinc from Met-Zinc in piglets and equivalent responses in plasma and tissue level of zinc in chickens for fattening fed diets were shown; consequently the additive Met-Zinc is considered an efficacious source of zinc for all animal species/categories.

Wednesday January 23, 2013/ EFSA/ European Union.
http://www.efsa.europa.eu

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