Jianqiang Zhang

Iowa State University - United States Author

6 Followers 2 Articles

Lora and Russ Talbot Professor in Veterinary Medicine

Education & Certifications

Ph.D. (2005) Veterinary Science (molecular virology), University of Kentucky, Lexington, KY
M.S. (1999) Molecular Virology, Chinese Academy of Preventive Medicine, Institute of Virology, Beijing, China
M.D. (1996) Beijing Medical University, School of Public Health, Beijing, China

Research Focus & Interests

Development and validation of diagnostic assays for viruses of veterinary significance
Genetic classification, pathogenicity, and cross protection of PRRSV
Pathogenesis, immune responses and vaccine development of swine enteric coronaviruses
Disinfectants and antivirals against various viruses

Honors & Awards

Iowa State University College of Veterinary Medicine International Service Award (2021)
MorrisTONE Faculty Fellowship (2020-2021)
Iowa State University Emerging Leaders Academy (2019-2020)
JVDI Best Full Manuscript Award (2018)
Zoetis Award for Veterinary Research Excellence (2016)
Iowa State University Award for Early Achievement in Research (2016)
ISU College of Veterinary Medicine Early-Career Achievement in Research Award (2015)

Jianqiang Zhang 6 Followers 2 Articles

Articles 2

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Figure 1: Representation of a recombination event generating a new virus. The region before and after the points where the two lines cross denote the portion of genomes received from the two parental viruses. Genome regions are shown at the top.

HealthArticle

The implications of the PRRSV recombination dilemma

PRRS control measures also reduce the opportunities for different wild-type viruses to recombine and create more aggressive strains.

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Figure 1: Schematic representation of a PRRSV whole genome (GenBank U87392) and the target regions for different diagnostic assays. In the United States, RT-PCR assays to detect modified live virus (MLV) vaccine-like viruses target the nsp2 region, and CLAMP sequencing to block amplification of MLV vaccine viruses during Sanger sequencing targets the ORF5 gene.

HealthArticle

PRRS Molecular diagnostics: when sequencing only 4% is not enough

Genetic mutation and evolution of PRRSV can occur across all genes. Unlike ORF5, which only represents about 4% of the PRRSV genome, NGS can recover a whole PRRSV genome to be used in epidemiological investigations.

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02-Jun-2025sonu-kumar_1hack

Jianqiang Zhang

Education & Certifications

Research Focus & Interests

Honors & Awards

The implications of the PRRSV recombination dilemma

PRRS Molecular diagnostics: when sequencing only 4% is not enough

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