Michael Zeller

Iowa State University - United States Author

6 Followers 2 Articles

B.S. Biochemistry, 2014 Iowa State University
Ph.D. Bioinformatics, 2020 Iowa State University

Updated CV 20-May-2025

Michael Zeller 6 Followers 2 Articles

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Figure 1: Representation of a recombination event generating a new virus. The region before and after the points where the two lines cross denote the portion of genomes received from the two parental viruses. Genome regions are shown at the top.

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The implications of the PRRSV recombination dilemma

PRRS control measures also reduce the opportunities for different wild-type viruses to recombine and create more aggressive strains.

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Figure 1: Schematic representation of a PRRSV whole genome (GenBank U87392) and the target regions for different diagnostic assays. In the United States, RT-PCR assays to detect modified live virus (MLV) vaccine-like viruses target the nsp2 region, and CLAMP sequencing to block amplification of MLV vaccine viruses during Sanger sequencing targets the ORF5 gene.

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PRRS Molecular diagnostics: when sequencing only 4% is not enough

Genetic mutation and evolution of PRRSV can occur across all genes. Unlike ORF5, which only represents about 4% of the PRRSV genome, NGS can recover a whole PRRSV genome to be used in epidemiological investigations.

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02-Jun-2025sonu-kumar_1hack

Michael Zeller

The implications of the PRRSV recombination dilemma

PRRS Molecular diagnostics: when sequencing only 4% is not enough

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