|Shiga toxin: the causative agent of Edema Disease|
|Pathogen:||Shiga toxin-producing E. coli strains (STEC/VETC)|
|Risk factors:||Transport, stress, moving, change of housing, change of feed, discontinuing the application of oral antimicrobials and / or zinc oxide|
|Course of the disease:||• Subacute / acute
• Prolonged course
• Sporadic occurrence
• Increased losses within a given time period
|Clinical signs:||Edema of eyelids, bridge of nose and larynx, croaky squealing, convulsions, ataxia, lateral position with paddling limbs, increased number of runts, sudden death|
|Gross pathology:||Edema can appear in all organs (e.g. gallbladder bed, mesocolon, bridge of nose, front head), mesenterial lymphnodes can be enlarged|
|Histopathology:||Edema of the brain (esp. in acute cases), vascular lesions (esp. in prolonged cases)|
|Impacts:||Increased number of deaths and runts, decreased daily weight gain, inhomogeneous groups of animals, psychological pressure for farmers and caretakers|
|Consequences:||Increased use of antimicrobials and / or zinc oxide:
• Risk of developing resistance and recurrence
Restricted weaning diet:
• Genetic potential will not be fulfilled, prolonged nursery, inhomogeneous groups of pigs, impacts also for the finishing period
|Shiga toxin: leaves distinct marks|
Detection rate of Shiga toxin-producing E. coli in farms suspicious for Edema Disease in a German
Number of farms with detection of Shiga toxin-producing E. coli
Effects of the vaccination in nursery period1
* on average of all evaluable farms
Nothing is as natural as the pig‘s own immunity. Actively boost the inherent immunity against Edema Disease by vaccination.
ECOPORC SHIGA suspension for injection for pigs. Qualitative and quantitative composition: Each dose of 1 ml contains: Active substance: Genetically modified recombinant Stx2e antigen: ≥ 3.2 x 106 ELISA units. Adjuvant: Aluminium hydroxide max. 3.5 mg. Excipient: Thiomersal max. 0.115 mg.
Indications for use: Active immunisation of piglets from the age of 4 days, to reduce the mortality and clinical signs of oedema disease caused by Stx2e toxin produced by E. coli (STEC). Onset of immunity: 21 days after vaccination.
Duration of immunity: 105 days after vaccination.
Contraindications: Do not use in case of hypersensitivity to the active substance, to the adjuvant or to any of the excipients. Adverse reactions: Commonly very small local reactions such as mild swelling at the injection site (maximum of 5 mm) may be observed, but these reactions are transient and subside within a short time (up to seven days) without treatment. Clinical signs such as temporary mild behavioural disturbances can uncommonly be observed after application of ECOPORC SHIGA. Commonly a slight rise in body temperature (maximum of 1.7 °C) may occur after injection. But these reactions subside within a short time (maximum of two days) without treatment.
Withdrawal period: Zero days. Under veterinary prescription only.
Marketing Authorisation Holder: IDT Biologika GmbH, Am Pharmapark, 06861 Dessau-Rosslau, Germany.
Shiga toxin causes more than Edema!
Nothing is as natural as the pig’s own immunity.
The one-time vaccination from which you benefit again and again.
|IDT Biologika GmbH
Am Pharmapark • D-06861 Dessau-Roßlau
Tel. +49 (0) 34901 885 5000 • www.idt-biologika.com